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Luvox is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).


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The almost inevitable consequence of chronic stress is depression. The rhythm of modern life makes one in ten people in developed countries take antidepressants. Let's talk about one of them, which was included in the list of the 300 most sold medicines in the world - Fluvoxamine.

What is FLUVOXAMINE (LUVOX, LUVOX CR)?

PRINCIPLE OF OPERATION

Fluvoxamine (Luvox) is one of the fairly mild and well-tolerated antidepressants that are related to serotonin reuptake inhibitors.

Its calming effect is mild, compared to other similar medications, and not too strong. But a powerful anti-anxiety effect can be used to treat anxiety and even obsessive-compulsive mental disorders (OCD).

The drug increases the level of serotonin due to the expansion of the synaptic cleft, which causes its antidepressant and anti-anxiety effect. It is prescribed mainly for anxiety depressions with sleep disorders. It works flawlessly in the standard dosage of 100 mg even in cases when Citalopram, Effexor, Sertraline, Remeron, Stimuloton, Abilify, Paroxetine, Coaxil Rexetin, Zoloft are powerless.

IMPACT ON THE EMOTIONAL SPHERE

When taking most antidepressants in the first 2-3 weeks of treatment, there is emotional arousal, reactively increased anxiety. Therefore, people have prescribed benzodiazepine tranquilizers in parallel, which provokes emotional instability and mood swings.

The advantage of Luvox over other similar drugs is that at first, it does not increase anxiety, and when taking it, you can do without tranquilizers. When mental and sexual abilities are preserved, emotional stability comes to the person. This applies even to people who were previously characterized by extreme emotional instability. Persistent mood improvement and even calmness are what Fluvoxamine provides immediately, from the first days of administration.

However, it is worth noting that the mood increase and relaxation state are less pronounced compared to other medications against depression.

NEUROPROTECTIVE EFFECT

In addition to the anti-anxiety effect, Fluvoxamine can positively affect nerve cells, their growth, and differentiation. In humans, the activity of neurons that block and activate anxiety is normally balanced. But if a mental disorder occurs, the nerve cells that are supposed to block anxiety are not activated for various reasons.

What do selective serotonin reuptake inhibitors, and Luvox in particular, do? They activate serotonin neurons that are designed to block anxiety.

In addition to this main function, the drug turned out to have three additional properties, to some extent mutually opposite.

  • Luvox does not have an analgesic effect.
  • It promotes neurogenesis.
  • It normalizes the architecture of sleep.

Scientists have recently found that pain and the growth of nerve cells with their synapses are interrelated things. If there is pain, then there is a growth of nerve cells, and this process is controlled by special receptors. Sigma-receptors are a very important target for psychotherapy, which will soon show itself. These Sigma receptors control special neurotransmitters that, on the one hand, cause the growth and differentiation of nerve cells, and on the other hand, increase the pain and speed of its conduction.

What does a medication called Luvox (Fluvoxamine) do? It increases the activity of these very Sigma receptors, and the neurotrophic factor becomes larger. Accordingly, the growth and differentiation of nerve tissue cells increases. This is a positive property of the drug, it can be called neuroprotective. But at the same time, there may be an increase in pain and the speed of its implementation.

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It also has another important effect, which is also associated with neuroprotection. It can delay, up to blocking, the metabolism of melatonin, more specifically, its decay. Melatonin is called a sleep hormone, it is produced only in the dark, and its amount decreases in the light. Melatonin is not just a sleep hormone, it is a substance that determines the architecture of sleep (its alternating phases), which are important for the growth and differentiation of structural units in the nervous tissue.

The formation of new nerve cells and synapses is possible only during a certain phase of sleep, and if their alternation is disrupted, then neurogenesis does not occur. Moreover, this whole process occurs only when melatonin reigns. Flexamin also blocks the breakdown of melatonin (causing deep sleep), which leads to an additional neuroprotective effect.

As a result, we have an anti-anxiety drug with actually a double neuroprotective effect.

Who needs neuroprotection?

This is of great importance in children who are learning, and they have intense growth and differentiation of brain tissue. Elderly people also need neurogenesis, because their aging neurons must be preserved. We also have a large number of strokes in our country, and we have a lot of elderly people with brain damage, often deeply damaged. These people, if they also have an anxiety disorder, very much need an active substance that will promote the formation of new nerve cells to replace the destroyed ones.

STIMULATING INTELLECTUAL ACTIVITY

Luvox increases the level of serotonin (a neurotransmitter and so-called "happiness hormone") in the synaptic cleft, this causes its antidepressant, anti-anxiety effect. Even though this drug has a pronounced sedative and anti-anxiety effect, its effect on the cognitive sphere leads to an improvement in mental activity. In this area, it works as a stimulant.

Many medications for depression (Paroxetine, etc.) have a depressing effect on the cognitive sphere. Benzodiazepine tranquilizers (Alprazolam, Phenazepam, Diazepam, Lorazepam) also work.

In this regard, Fluvoxamine differs favorably from them. Under its influence, on the contrary, attention is concentrated, the sharpness of vision is sharpened, thoughts become clearer, short-term and long-term memory is improved, and new material is quickly memorized. Moreover, all operations of thinking are accelerated and their accuracy increases. Developing:

  • Synthetic thinking (the ability to operate with complete objects).
  • Even more-analytical thinking (the ability to see details in the overall system).
  • Ability to quickly find cause-and-effect relationships.

Therefore, Luvox is recommended for children and adults engaged in mental work, who have some phenomena of cognitive deficit, a feeling of blurred sensations, etc. companions of depression.

Many people say, judging by the reviews, that along with the calmness under the influence of Fluvoxamine appeared:

  • clarity and clarity of thinking,
  • concentration of attention,
  • improved memory,
  • excellent perception of information,
  • development of imagination.

IMPROVED PERFORMANCE

Since under the influence of Luvox comes a stable emotional state and improves mood, there is a powerful motivation of a professional nature. People are beginning to strive to present themselves, communicate more, communicate, conduct dialogues. And it is not just social activity that is increasing, but professional activity, as well as working efficiency and productivity.

THE PRESERVATION OF SEXUAL ACTIVITY

As for the sexual sphere, Luvox is a psychomodulating agent that has the least effect on the sexual sphere, both in men and women. This is a plus for those people who want both an anti-anxiety effect and a sedative state with emotional stabilization but at the same time-a a minimal impact on the sexual sphere.

DISADVANTAGES

The main disadvantage of Fluvoxamine is that it interacts very actively with other drugs. In many cases, it dramatically increases their concentration in the blood. Which is dangerous in case of taking cardiac, antihypertensive, antidiabetic, and other medications. Cases of increasing the concentration of glucose in the blood when taking Luvox with other drugs are described by tens of times. This is why it should be prescribed and monitored by a doctor. Although you can Buy Luvox without a prescription in any commercial pharmacy.

PAIN SENSITIVITY DOES NOT DECREASE

This applies to many medications for depression – they often lead to a decrease in pain sensitivity. People who, along with psychosomatic disorders, had some pain, get rid of them. Pain often disappears in the treatment of depression. Even those that were not part of a depressive disorder, but accompanied somatic diseases. Painful sensations disappear, because under the influence of most antidepressants, pain sensitivity decreases, and its threshold increases.

In Luvox, one of The most unpleasant "side effects" is that it practically does not affect pain sensitivity. Sometimes there are some paradoxical reactions to Luvox, when some unpleasant sensations even increase, even to the point of unbearable. But this happens at high dosages, more often a person has a condition as if the whole body aches.

SIDE EFFECT

The body is individual for each person, and there may be quite unexpected individual mental reactions. As with any medication, the body can respond with individual intolerance. Most often, this is manifested by nausea.

It happens that a person has pain in various parts of the body that was not there before. In some areas, it is piercing, strong, even unbearable. But mostly it is more like some pulling or burning sensations and a state of aching. At the same time, you constantly want to move, at least stretch. But this happens at high dosages.

At first, some patients may experience increased sleepiness, but this quickly passes.

CONCLUSION

So, anti-anxiety and neuroprotective Luvox is intended for the treatment of anxiety depressive disorders that are not accompanied by pain. The drug is especially useful for intensively trained children and elderly patients with severe brain diseases. Then this medication is deployed in its entirety, providing a good therapeutic result. It is also good for socially active people engaged in intellectual work, but suffering from anxiety and obsessive neurotic thoughts on the background of depression.

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